ABSTRACT
Sixty-four out of 189 jaundiced patients at San Lazaro Hospital were defined as acute viral hepatitis cases. Of this number, 22 (34.4%) were positive for hepatitis A markers while 26 (40.6%) were positive for hepatitis B markers. Hepatitis D infection accounted for 1.6%, while non-A, non-B hepatitis accounted for 21.9%.
Subject(s)
Acute Disease , Adolescent , Adult , Aged , Female , Hepatitis A/diagnosis , Hepatitis Antibodies/analysis , Hepatitis B/diagnosis , Hepatitis B Surface Antigens/analysis , Hepatitis B virus/isolation & purification , Hepatitis C/diagnosis , Hepatitis D/diagnosis , Hepatitis Delta Virus/isolation & purification , Hepatitis, Viral, Human/diagnosis , Hepatovirus/isolation & purification , Humans , Immunologic Techniques , Jaundice/microbiology , Male , Middle Aged , PhilippinesABSTRACT
Human leucocyte antigens (HLA) were used as genetic markers in an attempt to determine possible host genetic susceptibility or resistance to malarial infections. HLA-A and B typing on lymphocytes from 68 confirmed P. falciparum and 77 P. vivax cases was compared with that found in 66 control subjects with no known history of malaria. A significant deviation was observed in the distribution of HLA-B27. This phenotype was absent in the P. falciparum group although found present in the P. vivax group (10%) and the control group (11%). Also, the combination of A9(w24) and B5 was significantly higher among the P. falciparum group than that found in the P. vivax and control groups. These findings require confirmation but do suggest the possibility of genetic susceptibility and that extensive genetic studies might be worth investigating.
Subject(s)
Disease Susceptibility , Female , HLA Antigens/analysis , HLA-A Antigens , HLA-B Antigens , Humans , Malaria/genetics , Male , Philippines , Plasmodium falciparum/immunology , Plasmodium vivax/immunologyABSTRACT
A study of chloroquine resistance of 54 isolates of Plasmodium falciparum is reported. Sixty-four percent of the isolates tested produced schizonts in vitro (micro-technique), whereas the remaining 36 percent did not. The accuracy of the in vitro test to predict in vivo resistance was increased when the primary parasite isolates were cultured in the presence of rabbit serum and when the cultures were allowed to incubate for more than 48 hours. Thirteen isolates of P. falciparum that showed in vitro resistance were confirmed in vivo resistant. Eleven of these cases were identified as R-I and two as R-II. Only one case of in vivo resistance (R-II) was observed among the 19 isolates that failed to produce schizonts in vitro.